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KMID : 0350519940470041717
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Journal of Catholic Medical College
1994 Volume.47 No. 4 p.1717 ~ p.1734
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Morphology and Topographic Distribution of Calbindinergic and Parvalbuminergic Neurons in the Rabbit Cervical Cord
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Abstract
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In transmembrane and intracellular sites of neuron, calcium ion(Ca++) has been known to have an important role of signalling process. It is now well accepted that calcium binding proteins, calbindin D-28K (calbindin) and parvalbumin, modulate and
mediate above calcium ions's action as a second messenger. Although it has been reported that calbindinergic and parvalbuminergic neurons comprise different subpopulations in the cat and rat spinal cords, the studies of their morphology,
topographical
distribution and ultrastructural features have been done extensively in the mammalian spinal cords until now. This study was conducte to localize calbidinergic and parvalbuminergic neurons and to define their morphology, topographical
distribution
and
ultrastructural features in the rabbit cervical cord by the preembedding immunocytochemical method using anti-calbindin and anti-parvalbumin antisera.
In the rabbit cervical cord, calbindin immunoreactive neurons were mainly distributed in the dorsal horn, especially in lamina ii, and a small number of labelled neurons were observed in the intermediate gray substance(IGS), but calbindin
immunoreactivities were not observed in the ventral horn. The somata of calbindin immunoreactive neurons synaptic from non-immunoreactive axom terminals in the dorsal horn and in the IGS. Parvalbumin immunoreactive neurons were mainly observed in
the
IGS and in the ventral horn, but only a few of parvalbumin immunoreactive neurons were distributed in the dorsal horn. In the ventral horn. Two types of parvalbumin immunoreactive neurons were identified according to the sizes of the somata and
labelled
motor cells received synaptic inputs from labelled and unlabelled axon terminals.
These results demonstrate that calbindinergic neurons are located in lamina ii of doral horn and a few of neurons located in the intermediate gray and parvalbuminergic neurons are located in the intermediate gray substance and in the ventral
horn,
and
these neurons comprise different subpopulations of neurons, and suggest that calbindinergic neurons might play an important role in the process of pain modulation and parvalbuminergic neurons, in the control of motor activity with their specific
synaptic circuitry in the spinal cord.
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KEYWORD
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